[3H]Diazepam binding in mammalian central nervous system: a pharmacological characterization.

Comparison of typical and atypical benzodiazepines on the central and peripheral benzodiazepine receptors.

The affinities of typical and atypical benzodiazepines (BZs) for 3H-flunitrazepam (FLU) and 3H-Ro 5-4864, "peripheral" BZ, binding sites in the central nervous system (CNS) were compared. Each dissociation constant (Kd) value of the 3H-FLU binding sites in the cerebellum, cortex, hippocampus and spinal cord showed the similar results, although the binding maximum (Bmax) for the cortex and cereb...

Quantitative autoradiographic distribution of L-[3H]glutamate-binding sites in rat central nervous system.

Quantitative autoradiography was used to determine the distribution of L-[3H]glutamate-binding sites in the rat central nervous system. Autoradiography was carried out in the presence of Cl- and Ca2+ ions. Scatchard plots and Hill coefficients of glutamate binding suggested that glutamate was interacting with a single population of sites having a K-D of about 300 nM and a capacity of 14.5 pmol/...

ANALYSIS OF DIAZEPAM USING HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC METHOD Introduction: Diazepam is a drug belonging to benzodiazepine group (7-chloro-1-methyl-5- phenyl-3H-1,4-benzodiazepine-2-one] known for its depression activity on the central nervous system

The Role of Mammalian Target of Rapamycine Signaling Pathway in Central Nervous System Cancers: A Review

Mammalian mechanistic target of rapamycine (mTOR) is a conserved serine/threonine kinase in the cellular PI3K/Akt/mTOR signaling pathway. This pathway is modified by cellular alterations such as level of energy, growth factors, stresses, as well as the increased environmental level of cancerous cytokines. In general, increase of this kinase protein function is seen in various types of cancers, ...

Neuro-pharmacological effects of Crinum zeylanicum in mice

Objectives: The aim of present study was to evaluate some effects of Crinum zeylanicum (C. zeylanicum) on central nervous system. Materials and Methods: C. zeylanicum methanolic bulb extract (250-1000 mg/kg orally), 2 mg chlorpromazine and 4 mg diazepam /kg body weight intraperitoneally respectively were tested in mice using Irwin test, pentobarbitone-induced sleep test, spontaneous motor acti...